Harnessing the power of proteomics for identification of oncogenic, druggable signalling pathways in cancer

摘要: ABSTRACTIntroduction: Genomic and transcriptomic profiling of tumours has revolutionised our understanding cancer. However, the majority possess multiple mutations, determining which oncogene, or even pathway, to target is difficult. Proteomics emerging as a powerful approach identify functionally important pathways driving these cancers, how they can be targeted therapeutically.Areas covered: The authors provide technical overview mass spectrometry based approaches for proteomic profiling, review current strategies available identification dysregulated networks, pathways, drug targets in cancer cells, with key focus on ability profile kinomes. potential applications clinic are also highlighted.Expert opinion: addition information genomic platforms – ‘proteogenomics’ providing unparalleled insight cell biology. Application improved spectr...