Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.

摘要: Two patients who developed cholestatic liver disease after exposure to antibiotics are described. One patient received clindamycin had biopsy findings of marked cholestasis, portal inflammation, bile duct injury and paucity (ductopenia). A second clinical improvement showed resolution cholestasis but persistence paucity. Three years later, treatment with ampicillin caused another episode hepatitis on rebiopsy. The patient, receiving trimethoprim-sulfamethoxazole, in the biopsy. This is first description, our knowledge, ductopenia apparently by