A Reality of the 21st Century

作者： Edith Tzeng , Brian S. Zuckerbraun

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摘要: Current therapies for the treatment of atherosclerotic vascular disease are aimed at either disrupting or bypassing flow-limiting lesions. Preventative strategies necessary to decrease burden but limited by genetic predispositions certain diseases and body’s innate response injury. Gene therapy, defined as purposeful therapeutic overexpression attenuation a gene product, has enormous potential benefits in prevention strategies. This article reviews scientific considerations involved development therapy outlines some products that currently being used. These interventional approaches will be reviewed context specific processes, including atherosclerosis, restenosis, thrombosis. serve an enhancing adjuvant role evolving surgical therapies.

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参考文章(66)

E. F. Unger, S. Banai, M. Shou, D. F. Lazarous, M. T. Jaklitsch, M. Scheinowitz, R. Correa, C. Klingbeil, S. E. Epstein, Basic fibroblast growth factor enhances myocardial collateral flow in a canine model American Journal of Physiology-heart and Circulatory Physiology. ,vol. 266, ,(1994) , 10.1152/AJPHEART.1994.266.4.H1588

Steven R Bailey, Mechanisms of delivery and local drug delivery technologies. Seminars in interventional cardiology : SIIC. ,vol. 1, pp. 17- 23 ,(1996)

Edith Tzeng, Larry L. Shears, Paul D. Robbins, Bruce R. Pitt, David A. Geller, Simon C. Watkins, Richard L. Simmons, Timothy R. Billiar, Vascular Gene Transfer of the Human Inducible Nitric Oxide Synthase: Characterization of Activity and Effects on Myointimal Hyperplasia Molecular Medicine. ,vol. 2, pp. 211- 225 ,(1996) , 10.1007/BF03401618

Peter Carmeliet, VEGF gene therapy: stimulating angiogenesis or angioma-genesis? Nature Medicine. ,vol. 6, pp. 1102- 1103 ,(2000) , 10.1038/80430

J.M. Wilson, In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. Journal of Biological Chemistry. ,vol. 269, pp. 13695- 13702 ,(1994) , 10.1016/S0021-9258(17)36886-2

M D Hoggan, W W Hauswirth, K I Berns, A K Cheung, Integration of the adeno-associated virus genome into cellular DNA in latently infected human Detroit 6 cells. Journal of Virology. ,vol. 33, pp. 739- 748 ,(1980) , 10.1128/JVI.33.2.739-748.1980

E. Nabel, G Plautz, G. Nabel, Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Science. ,vol. 249, pp. 1285- 1288 ,(1990) , 10.1126/SCIENCE.2119055

Melina R. Kibbe, Optimizing Cardiovascular Gene Therapy Archives of Surgery. ,vol. 135, pp. 191- 197 ,(2000) , 10.1001/ARCHSURG.135.2.191

LJ Feldman, CJ Pastore, N Aubailly, M Kearney, D Chen, M Perricaudet, PG Steg, JM Isner, Improved efficiency of arterial gene transfer by use of poloxamer 407 as a vehicle for adenoviral vectors Gene Therapy. ,vol. 4, pp. 189- 198 ,(1997) , 10.1038/SJ.GT.3300382

10.

Tatiana V. Petrova, Taija Makinen, Kari Alitalo, Signaling via Vascular Endothelial Growth Factor Receptors Experimental Cell Research. ,vol. 253, pp. 117- 130 ,(1999) , 10.1006/EXCR.1999.4707

A Reality of the 21st Century

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A Reality of the 21st Century

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