Quality of Life End Points in Cancer Clinical Trials: Review and Recommendations

摘要: In this presentation, issues that influenced the development of policies for inclusion quality life end points in certain Southwest Oncology Group clinical trials are reviewed. The key recommended by us and adopted Cancer Control Research Committee as follows: (a) Begin assessment specific types phase III protocols. (b) Always measure physical functioning, emotional symptoms (general protocol specific), global separately. (c) Include measures social functioning additional protocol-specific if resources permit. (d) Use patient-based questionnaires with psychometric properties have been documented published studies. review, we also recommend questionnaires. Our recommendations may prove useful other cancer groups multi-institution treatment chronic diseases.