Hexose sugars differentially alter collagen gene expression and synthesis in fibroblasts derived from granulation tissue, hypertrophic scar and keloid.
作者： Jyrki K�ssi , Marko V�h�-Kreula , Juha Peltonen , Juha Risteli , Matti Laato
DOI: 10.1007/S00403-004-0461-8
关键词:
摘要: Clinical observations have suggested that sugar and honey enhance granulation tissue formation in vitro studies shown monosaccharide sugars stimulate mesenchymal endothelial cells. In this study, the effects of glucose, fructose, galactose mannose on type I III collagen gene expression synthesis were studied tissue, hypertrophic scar keloid fibroblast cultures. Glucose elevated both mRNAs fibroblasts. Fructose increased mRNA almost sevenfold Galactose caused an increase fibroblasts but, contrast, decreased levels Analysis aminoterminal propeptides (PINP PIIINP) revealed glucose amount PINP fibroblasts, whilst fructose all cell lines studied. a decrease but was seen only Mannose PIIINP The effect ratio I/type negligible or decreasing with exception galactose, which results suggest no significant value stimulation vitro. may prevention treatment abnormal scars.
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