Urinary Neutrophil-Gelatinase Associated Lipocalin is a Potential Noninvasive Marker for Renal Scarring in Patients With Vesicoureteral Reflux
作者： Manabu Ichino , Mamoru Kusaka , Yoko Kuroyanagi , Terumi Mori , Masashi Morooka
DOI: 10.1016/J.JURO.2010.01.031
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摘要: Purpose: Renal scarring is a serious complication that often occurs with chronic pyelonephritis in the presence of vesicoureteral reflux. In previous study we established rat model renal which found up-regulation neutrophil-gelatinase associated lipocalin at mRNA and protein levels. this evaluated urinary as potential biomarker for progression patients reflux.Materials Methods: A total 34 diagnosed reflux without evidence current tract infection 28 normal healthy children were enrolled study. scars by 99mtechnetium dimercapto-succinic acid scan 24 cases. Urinary levels monitored ELISA.Results: subjects was high during infancy, decreased rapidly within following ...
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