Age-Related Resistance of C57BL/6 Mice to Cryptococcus neoformans Is Dependent on Maturation of NKT Cells
作者： Rebecca Blackstock , Juneann W. Murphy
DOI: 10.1128/IAI.72.9.5175-5180.2004
关键词:
摘要: Conflicting results have been reported regarding the ability of C57BL/6 mice to clear infections due Cryptococcus neoformans. Examination various experimental protocols used suggested that might develop resist infection as they mature. We analyzed different ages respond immunization with cryptococcal antigen or a infection. Mice were immunized soluble culture filtrate (CneF) emulsified in complete Freund's adjuvant (CneF-CFA). Delayed-type hypersensitivity (DTH) reactions elicited by significantly stronger 15-week-old than 7-week-old mice. Analysis CFU 8 weeks following intratracheal revealed relative inability younger animals control Six-week-old and infected cleared cryptococci from brain, spleen, liver manner similar However, older much more efficiently lungs. The possible role for NKT cells was determined passive transfer thymocytes 10-week-old (containing mature cells) 2-week-old immature 6-week-old enhanced DTH response after CneF-CFA, while treated did not improve their immunization. thymocyte population responsible improvement responses identified being NK1.1 positive.
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