Co-delivery of docetaxel and Poloxamer 235 by PLGA–TPGS nanoparticles for breast cancer treatment
作者： Xiaolong Tang , Yong Liang , Xiaojun Feng , Rongbo Zhang , Xu Jin
DOI: 10.1016/J.MSEC.2015.01.033
关键词:
摘要: Multidrug resistance (MDR) is a major hurdle to the success of cancer chemotherapy. Poloxamers have been shown reverse MDR by inhibiting P-glycoprotein (P-gp) pump. The objective this research test feasibility docetaxel-loaded PLGA-TPGS/Poloxamer 235 nanoparticles overcome in docetaxel-resistant human breast cell line. Docetaxel-loaded were prepared modified nanoprecipitation method using PLGA-TPGS and mixture, respectively. spherical shape rough porous surface. which had an average size around 180nm with narrow distribution stable, showing almost no change particle surface charge during 3-month storage period. vitro drug release profile both nanoparticle formulations showed biphasic pattern. There was increased level uptake (PPNPs) line, MCF-7/TXT, comparison (PTNPs). produced significantly higher toxicity than formulation Taxotere® vivo, indicating significant potential for treatment cancer.
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