Intracellular Neural Recording with Pure Carbon Nanotube Probes

摘要: The computational complexity of the brain depends in part on a neuron’s capacity to integrate electrochemical information from vast numbers synaptic inputs. measurements activity that are crucial for mechanistic understanding function also challenging, because they require intracellular recording methods detect and resolve millivolt- scale potentials. Although glass electrodes widely used recordings, novel with superior mechanical electrical properties desirable, could extend challenging environments, including long term recordings freely behaving animals. Carbon nanotubes (CNTs) can theoretically deliver this advance, but difficulty assembling CNTs has limited their application coating layer or assembly planar substrate, resulting more suitable vivo extracellular isolated cells. Here we show novel, yet remarkably simple, millimeter-long electrode sub-micron tip, fabricated self-entangled pure be obtain vertebrate neurons vitro vivo. This fabrication technology provides new method CNTs, affording promising opportunity harness nanotechnology neuroscience applications.