Acquired von Willebrand disease as a cause of recurrent mucocutaneous bleeding in primary thrombocythemia: Relationship with platelet count

摘要: We present a 4-year follow-up of 42-year-old patient with primary thrombocythemia whose clinical course was complicated by two major mucocutaneous bleeding episodes. On both occasions an acquired functional von Willebrand factor deficiency demonstrated. In contrast to what is reported in the literature, inverse relationship between platelet number and plasma high-molecular-weight multimers established.