Essential thrombocythemias: clinical evolutionary and biological data

摘要: This retrospective study reviewed 94 patients, aged 6 to 90 years, with thrombocythemia. The women/men ratio was 1.76. At onset or, less commonly, during the course of disease, 45% patients presented hemorrhagic manifestations, 29% thrombotic complications, and only 14% association hemorrhage thrombosis. average platelet count 1200 X 10(9)/1, no difference according sex or age. Platelet hypoaggregation seen in practically all cases (94%), although myelofibrosis frequent (54%). frequency hemorrhages increased when above 1000 10(9)/1 (P than 0.01), but occurrence thrombosis correlated neither nor thrombopathy. Survival time lengthy: 80% survival (standard error 6%) observed at 100 months. Transformation acute leukemia five patients. Because disease is most often prolonged, therapeutic measures must be conservative: anti-aggregating drugs small doses, chemotherapy beginning nonalkylating agents.