The association of microalbuminuria with aortic stiffness is independent of C-reactive protein in essential hypertension.

摘要: BACKGROUND It has not been fully elucidated whether microalbuminuria (MAU) and high-sensitivity C-reactive protein (hsCRP) are associated with aortic distensibility independently of each other. Our study was aimed to evaluate the independent relationships urinary albumin excretion rate (AER) hsCRP stiffness in hypertensive patients. METHODS We enrolled 140 untreated nondiabetic essential hypertensives (mean age: 48 +/- 12 years). In all subjects, 24-hour AER plasma levels were determined by immunoenzymatic assay. MAU defined as an 20-200 microg/min. Aortic assessed measurement carotid-femoral pulse wave velocity (PWV). RESULTS Carotid-femoral PWV, adjusted for age mean arterial pressure (MAP), higher subjects (n = 41) than those without it 99) (11.6 2.3 vs. 9.9 1.8 m/s; P < 0.001) above median value when compared lower (10.8 2.1 10 0.026). multiple regression analysis, hsCPR remained predictors (beta 0.24; 0.001 beta 0.15; 0.03, respectively). CONCLUSIONS results suggest that patients hypertension, CRP increased stiffness.