The combined effect of albuminuria and inflammation on all-cause and cardiovascular mortality in nondiabetic persons

摘要: . Objectives and design.  Recent studies have shown that albuminuria accompanied by evidence of subclinical inflammation is more strongly associated with metabolic abnormalities the development atherosclerosis than alone. The aim this population-based prospective study was to examine combined effect inflammatory markers on all-cause cardiovascular-mortality in nondiabetic individuals without macroalbuminuria. Subjects methods.  Urinary albumin creatinine, some (fibrinogen, white blood cell monocyte count) cardiovascular risk factors were measured 5702 persons Tromso, Norway. Baseline data collected 1994–1995 follow-up through 2005. Results.  For a one standard deviation higher value log-transformed ratio between creatinine (ACR), mortality rate for 1.21 when adjusted age, gender, established as well fibrinogen count (P < 0.001). corresponding 1.24 Persons upper quartile both ACR either had an age- gender-adjusted four times subjects lowest quartiles (P < 0.001). Conclusion.  predicts known diabetes macroalbuminuria. especially high amongst elevated levels markers.