Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder

摘要: Background Glial cells are more numerous than neurons in the cortex and crucial to neuronal function. There is evidence for reduced size schizophrenia, with suggestive glial cell density mood disorders. In this investigation, we have simultaneously assessed anterior cingulate major depressive disorder, bipolar disorder. Methods We examined tissue from area 24b of supracallosal 60 postmortem brain specimens 4 groups 15 subjects, as follows: normal controls. were all subjects using nucleator optical disector. Results (22%) ( P = .004) (23%) .01) layer 6 disorder compared was some (20%) .02) schizophrenia controls, before adjusting multiple layerwise comparisons, but there no significant changes size. differences or Neuronal similar that found Conclusion These findings suggest frontal cortical