摘要: New imaging techniques can see into the functioning brain, revealing regions that are active during certain tasks and sensations. Magistretti et al., in their Perspective, take this notion one step further and, by careful analysis of biochemistry gives rise to signals, they deduce some cellular molecular events accompany neuronal activity working ultimately laying groundwork for determining underlies human cognition.
sciencemag.org
unirioja.es参考文章(7)
Dwight E Bergles, Craig E Jahr, Synaptic Activation of Glutamate Transporters in Hippocampal Astrocytes Neuron. ,vol. 19, pp. 1297- 1308 ,(1997) , 10.1016/S0896-6273(00)80420-1
Philippe G. Bittar, Yves Charnay, Luc Pellerin, Constantin Bouras, Pierre J. Magistretti, Selective Distribution of Lactate Dehydrogenase Isoenzymes in Neurons and Astrocytes of Human Brain Journal of Cerebral Blood Flow and Metabolism. ,vol. 16, pp. 1079- 1089 ,(1996) , 10.1097/00004647-199611000-00001
N. R. Sibson, A. Dhankhar, G. F. Mason, D. L. Rothman, K. L. Behar, R. G. Shulman, Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 316- 321 ,(1998) , 10.1073/PNAS.95.1.316
D. L. Rothman, O. A. Petroff, K. L. Behar, R. H. Mattson, Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 5662- 5666 ,(1993) , 10.1073/PNAS.90.12.5662
L. Pellerin, P. J. Magistretti, Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 10625- 10629 ,(1994) , 10.1073/PNAS.91.22.10625
Graeme F. Mason, Rolf Gruetter, Douglas L. Rothman, Kevin L. Behar, Robert G. Shulman, Edward J. Novotny, Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR Journal of Cerebral Blood Flow and Metabolism. ,vol. 15, pp. 12- 25 ,(1995) , 10.1038/JCBFM.1995.2
Avital Schurr, James J. Miller, Ralphiel S. Payne, Benjamin M. Rigor, An Increase in Lactate Output by Brain Tissue Serves to Meet the Energy Needs of Glutamate-Activated Neurons The Journal of Neuroscience. ,vol. 19, pp. 34- 39 ,(1999) , 10.1523/JNEUROSCI.19-01-00034.1999