Thyroglobulin measurement in fine‐needle aspirate washouts: the criteria for neck node dissection for patients with thyroid cancer

摘要: Summary Background  Several studies report that detection of thyroglobulin (Tg) in fine-needle aspiration (FNA) biopsy washout fluid from lymph nodes identifies recurrences/metastases differentiated papillary thyroid cancer (DPTC) the neck with higher sensitivity and specificity than cytology (FNAC). However, diagnostic FNA-Tg cutoff values have not yet been established. Objective  To determine an appropriate threshold value for Tg levels FNA patients node metastases or recurrences DPTC. Design  We performed ultrasound (US)-guided FNAC measured (FNA-Tg). Final diagnoses were confirmed by histological examination excised specimens follow-up examinations at least 24 months. Patients  A total 168 ultrasonographically detected DPTC included. Measurements  In comparison FNAC, we evaluated sensitivity, accuracy metastasis according to several predetermined levels: 1, 10, 100 ng/ml, mean+2SD node-negative patients, FNA-Tg/serum-Tg > 1. Results  The was lowest 77·3% alone. lower showed whereas specificity. addition results, 95·0% 81·6% specificity, 92·6% positive predictive (PPV) 87·0% negative (NPV) level 10 ng/ml, serum-Tg patients. after surgery waiting surgery. Conclusion  measurement as well should be either before evaluate carcinomas. recommend > 10 ng/ml if is available reference.