Comparative therapeutic index, lethal time and safety margin of various toxicants and snake antivenoms using newly derived and old formulas

摘要: The assessment of clinical efficacy and toxicity is very important in pharmacology toxicology. effects psychostimulants (e.g. amphetamine), psychotomimetics Cannabis sativus) snake antivenoms are sometimes unpredictable even at lower doses, leading to serious intoxication fatal consequences. Hence, there need re-assess some formulas for calculation therapeutic index, lethal time safety margin with a view identifying agents remarkable potentials. index formula $$\left[ {T_{1} = 3\left( {W_{a} \times 10^{ - 4} } \right)} \right]$$ was derived from T1 = LD50/ED50 ED50 = $$\frac{{LD_{50} }}{3} x W_{a} 4}$$. Findings have shown that, function death reversal (s), factor (10−4) weight animal (Wa). However, the new {MS \sqrt[3]{{\frac{{LT_{50} }}{{LD_{50} }}}} \frac{1}{{ED_{99} }}} LT50 = $$\frac{{LD_{50} }}{{D_{1}^{p} }}$$ MS = $$\frac{{LD_{1} }}{{ED_{99} shows that cube root ratio between LT50 LD50 ED100th. Concentration (k) toxicant receptor {K \frac{1}{{T^{n} D1 × Tn = K LD1 = $$\sqrt[3]{{\frac{{LT_{50} }}}}$$ drug or concentration receptor, drug-receptor interaction dose administered particular time.