What can we learn from animal models of convulsive status epilepticus

摘要: Animal models of convulsive status epilepticus (SE) are essential tools for studying human SE and developing novel therapies. Although they do not exhibit the prolonged“silent period” that is characteristic typical mesial temporal lobe epilepsy (mTLE) patient, have proven invaluable investigating pathophysiology seizure-induced brain damage. Recurrent spontaneous seizures also make them useful antiepileptic drug screening, albeit only a subset patients who experience frequent, seizures. Chemoconvulsant-based particularly relevant to those survived prolonged severe damage with no apparent latent period. promising results been obtained from animal models, translating into trials has difficult. This may be due several important differences disease, including etiology, neuropathology, seizure manifestation. Provided their limitations acknowledged respected, will continue produce data years come.