Furosemide terminates limbic status epilepticus in freely moving rats.
作者： Martin Holtkamp , Julia Matzen , Katharina Buchheim , Matthew C. Walker , Hartmut Meierkord
DOI: 10.1046/J.1528-1157.2003.14003.X
关键词:
摘要: Summary: Purpose: To evaluate the anticonvulsant properties of furosemide and to determine sedative side effects compared with pentobarbital diuretic saline-treated controls in an experimental model limbic status epilepticus. Methods: Self-sustaining epilepticus was induced rats by continuous electrical stimulation perforant path. Five minutes after end stimulation, animals were given 100 mg/kg furosemide, 30 pentobarbital, or equal amount saline, intraperitoneally. After administration substance, monitored clinically electrographically for 3 h regarding epilepticus, level sedation, diuresis. Results: In seven 10 animals, terminated 68 ± 26 min, whereas successful all 5 0.8 min. contrast sedation did not occur furosemide. Weight loss 10.2 1.7% 6.5 1.1% saline (p < 0.001). Conclusions: The results suggest that may serve as alternative additional agent refractory complex partial patients whom common anesthetics are justifiable. Key Words: Status epilepticus—Experimental epilepsy model—Freely moving rat—Furosemide.
sci-hub.se 参考文章(25)
S. Javaheri, W. Corbett, J. M. Adams, P. J. Davis, P. S. Gartside, Acute respiratory acidosis: large-dose furosemide and cerebrospinal fluid ions. Journal of Applied Physiology. ,vol. 76, pp. 2651- 2655 ,(1994) , 10.1152/JAPPL.1994.76.6.2651
D. W. Hochman, S. C. Baraban, J. W. M. Owens, P. A. Schwartzkroin, Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity. Science. ,vol. 270, pp. 99- 102 ,(1995) , 10.1126/SCIENCE.270.5233.99
P.W Kaplan, No, some types of nonconvulsive status epilepticus cause little permanent neurologic sequelae (or : « The cure may be worse than the disease ») Neurophysiologie Clinique-clinical Neurophysiology. ,vol. 30, pp. 377- 382 ,(2000) , 10.1016/S0987-7053(00)00238-0
K.U Gutschmidt, K Stenkamp, K Buchheim, U Heinemann, H Meierkord, Anticonvulsant actions of furosemide in vitro. Neuroscience. ,vol. 91, pp. 1471- 1481 ,(1999) , 10.1016/S0306-4522(98)00700-3
Peter W. Kaplan, Assessing the outcomes in patients with nonconvulsive status epilepticus: nonconvulsive status epilepticus is underdiagnosed, potentially overtreated, and confounded by comorbidity. Journal of Clinical Neurophysiology. ,vol. 16, pp. 341- 352 ,(1999) , 10.1097/00004691-199907000-00006
Stephan A. Mayer, Jan Claassen, Johnny Lokin, Felicia Mendelsohn, Lyle J. Dennis, Brian-Fred Fitzsimmons, Refractory Status Epilepticus Archives of Neurology. ,vol. 59, pp. 205- 210 ,(2002) , 10.1001/ARCHNEUR.59.2.205
Avinash Prasad, John M. Williamson, Edward H. Bertram, Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus. Annals of Neurology. ,vol. 51, pp. 175- 181 ,(2002) , 10.1002/ANA.10085
GraemeJ. Hankey, EdwardG. Stewart-Wynne, MANAGEMENT OF NON-CONVULSIVE STATUS EPILEPTICUS The Lancet. ,vol. 329, pp. 1427- ,(1987) , 10.1016/S0140-6736(87)90610-6
Michael J. Aminoff, Do nonconvulsive seizures damage the brain?--No. JAMA Neurology. ,vol. 55, pp. 119- 120 ,(1998) , 10.1001/ARCHNEUR.55.1.119
Dan Torbati, Jeronimo Ramirez, Ellis Hon, Maria T. Camacho, Jeffrey B. Sussmane, Andre Raszynski, Jack Wolfsdorf, Experimental critical care in rats: gender differences in anesthesia, ventilation, and gas exchange. Critical Care Medicine. ,vol. 27, pp. 1878- 1884 ,(1999) , 10.1097/00003246-199909000-00028