Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus.
作者： Avinash Prasad , John M. Williamson , Edward H. Bertram
DOI: 10.1002/ANA.10085
关键词:
摘要: To examine the effect of therapy on status epilepticus (SE) acutely and long-term outcome, we compared three drugs with different mechanisms. Phenobarbital, MK-801, phenytoin were administered at 1, 2, 4 hours after initiation limbic by "continuous" hippocampal stimulation in rats. We evaluated effects these course SE subsequent development chronic epilepsy. Phenobarbital MK-801 superior to suppressing preventing There was no benefit if treatment given 2 SE. most effective electrographic seizure activity, but had a slightly wider window for prevention Early treatment, rather than suppression SE, correlated This study shows that administered, which have mechanisms action, clear differences altering outcomes. The findings suggest studies should itself, as well benefits each treatment. use N-methyl-D-aspartate receptor antagonists be considered early
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