Intradiscal Methylene Blue Injection for Discogenic Low Back Pain: A Meta‐Analysis
作者： Xiaohui Guo , WenYuan Ding , LanZe Liu , SiDong Yang
DOI: 10.1111/PAPR.12725
关键词:
摘要: OBJECTIVES The purpose of this study was to assess the effects intradiscal methylene blue (MB) injection on discogenic low back pain (DLBP). METHODS We conducted an electronic search PubMed, Ovid, Ovid MEDLINE and Embase databases using terms "low pain" "methylene blue"; limited English language articles from database inception October 2017. In addition, reference lists all included studies were manually searched. Two reviewers independently assessed quality studies, extracted data analyzed data. RESULTS Five included. results meta-analysis indicated that MB between preoperation postoperation DLBP statistically significant based 3-month visual analog scale (VAS) or numeric rating (NRS) (weighted mean difference [WMD] = 3.61; 95% confidence interval [CI]: 2.46 4.76; P < 0.05) Oswestry Disability Index (ODI) (WMD = 24.64, CI: 12.07 37.21, P < 0.05), 6-month VAS NRS (WMD = 2.95; 1.20 4.71; ODI (WMD = 23.21, 12.89 33.53, 12-month (WMD = 3.19; 0.99 5.40; (standard difference = 29.51, 20.60 38.42, P < 0.05). CONCLUSIONS Intradiscal can reduce severity improve score in individuals with pain. Although seems be a safe effective treatment for pain, clinical benefits patients need further appraised larger samples more in-depth studies.
sci-hub.se 参考文章(36)
Mohan Radhakrishna, Gaurav Gupta, Jeffrey Chankowsky, Juan Francisco Asenjo, Methylene blue in the treatment of discogenic low back pain. Pain Physician. ,vol. 15, pp. 333- 338 ,(2012)
Jessica M. Ketchum, Thomas R. Saullo, Michael J. DePalma, Ben L. Laplante, Multivariable analysis of the relationship between pain referral patterns and the source of chronic low back pain. Pain Physician. ,vol. 15, pp. 171- 178 ,(2012) , 10.36076/PPJ.2012/15/171
Michael J. DePalma, Jessica M. Ketchum, Thomas Saullo, What is the source of chronic low back pain and does age play a role Pain Medicine. ,vol. 12, pp. 224- 233 ,(2011) , 10.1111/J.1526-4637.2010.01045.X
Michael DePalma, Jessica Ketchum, Thomas Saullo, Jerome Schofferman, Structural Etiology of Chronic Low Back Pain Due to Motor Vehicle Collision Pain Medicine. ,vol. 12, pp. 1622- 1627 ,(2011) , 10.1111/J.1526-4637.2011.01246.X
Shiv K. Sharma, Jonathan O. Jones, Pablo P. Zeballos, Stephen A. Irwin, Thomas W. Martin, The prevention of discitis during discography. The Spine Journal. ,vol. 9, pp. 936- 943 ,(2009) , 10.1016/J.SPINEE.2009.06.001
Shruti Gupta Kapoor, Jeremy Huff, Steven P. Cohen, Systematic review of the incidence of discitis after cervical discography. The Spine Journal. ,vol. 10, pp. 739- 745 ,(2010) , 10.1016/J.SPINEE.2009.12.022
Gen-Zhe Liu, Hirokazu Ishihara, Ryusuke Osada, Tomoatsu Kimura, Haruo Tsuji, Nitric oxide mediates the change of proteoglycan synthesis in the human lumbar intervertebral disc in response to hydrostatic pressure. Spine. ,vol. 26, pp. 134- 141 ,(2001) , 10.1097/00007632-200101150-00005
Marcus Schiltenwolf, Christian Fischer, Pierre Kunz, How perfect studies may be? Comment on Peng et al. A randomized placebo-controlled trial of intradiscal methylene blue injection for the treatment of chronic discogenic low back pain. Pain 2010;149:124–9 Pain. ,vol. 152, pp. 954- ,(2011) , 10.1016/J.PAIN.2011.01.008
Maarten H. Coppes, Enrico Marani, Raph T. W. M. Thomeer, Gerbrand J. Groen, Innervation of "painful" lumbar discs. Spine. ,vol. 22, pp. 2342- 2349 ,(1997) , 10.1097/00007632-199710150-00005
Ernesto B. Eusebio, James Graham, Nat Mody, Treatment of intractable pruritus ani Diseases of The Colon & Rectum. ,vol. 33, pp. 770- 772 ,(1990) , 10.1007/BF02052324