Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult.

摘要: We sequenced and analyzed the genome of a commensal Escherichia coli (E. coli) strain SE11 (O152:H28) recently isolated from feces healthy adult classified into E. phylogenetic group B1. harbored 4.8 Mb chromosome encoding 4679 protein-coding genes six plasmids 323 genes. None had sequence similarity to known phage- plasmid-borne virulence factors found in pathogenic strains. The comparative analysis with laboratory K-12 MG1655 identified 62 poorly conserved between these two non-pathogenic strains 1186 absent MG1655. These were mostly encoded large insertion regions on or plasmids, notably abundant fimbriae autotransporters, which are cell surface appendages that largely contribute adherence ability bacteria host cells bacterial conjugation. data suggest may have evolved acquire accumulate functions advantageous for stable colonization intestinal cells, adhesion-associated important commensality human gut habitat.