Type 2 diabetes mellitus: what is the optimal treatment regimen?

摘要: Treatment options for type 2 diabetes mellitus currently consist of insulin sensitizers, α-glucosidase inhibitors, secretagogues, and insulin. However, the emphasis on initial therapy has been shifting from secretagogues inhibitors to sensitizers such as metformin thiazolidinediones (TZDs). This article outlines benefits treatment with vis a part comprehensive algorithm diabetes. Secretagogues effectively lower plasma glucose levels only, whereas reduce several important cardiac risk factors in addition reducing levels. TZDs, particular, are also beneficial their ability preserve or even rejuvenate pancreatic β-cell function. The layered approach, beginning combination insulin-sensitizer incrementally progressing triple oral and, if necessary, subcutaneous maintain glycemic control.