Lipid Peroxidation and Haloalkylation in CCl4-Induced Liver Fatty Degeneration and Necrosis

摘要: Liver fatty accumulation following acute CCl4 poisoning is triggered by a block of lipoprotein secretion which occurs very soon after treatment.1,2 Various steps the secretory pathway are probably involved in expression such damage. Recent studies with isolated rat hepatocytes have shown marked impairment maturation and transport micelles at level Golgi apparatus CCl4.3. In present paper demonstration early disturbances liver function occurring whole animal dosed reported, together on pathogenesis this cellular perturbation. addition, relative role played CCl4-dependent alkylation macromolecules lipid peroxidation necrogenic effect toxin has been evaluated vivo experiments.