Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25
作者： Saverio Marchi , Laura Lupini , Simone Patergnani , Alessandro Rimessi , Sonia Missiroli
DOI: 10.1016/J.CUB.2012.11.026
关键词:
摘要: The recently discovered mitochondrial calcium uniporter (MCU) promotes Ca(2+) accumulation into the matrix. We identified in silico miR-25 as a cancer-related MCU-targeting microRNA family and demonstrate that its overexpression HeLa cells drastically reduces MCU levels uptake, while leaving other parameters cytosolic signals unaffected. In human colon cancers cancer-derived cells, is overexpressed accordingly silenced. miR-25-dependent reduction of uptake correlates with resistance to apoptotic challenges can be reversed by anti-miR-25 overexpression. Overall, data targeting signaling favors cancer cell survival, thus providing mechanistic insight role mitochondria tumorigenesis identifying novel therapeutic target neoplasia.
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sci-hub.se 参考文章(26)
Zhiling Zhu, MiR-25 Regulates Apoptosis by Targeting Bim in Human Ovarian Cancer Oncology Reports. ,vol. 27, pp. 594- 598 ,(2011) , 10.3892/OR.2011.1530
Luca Scorrano, Scott A Oakes, Joseph T Opferman, Emily H Cheng, Mia D Sorcinelli, Tullio Pozzan, Stanley J Korsmeyer, BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis Science. ,vol. 300, pp. 135- 139 ,(2003) , 10.1126/SCIENCE.1081208
Diego De Stefani, Anna Raffaello, Enrico Teardo, Ildikò Szabò, Rosario Rizzuto, A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter Nature. ,vol. 476, pp. 336- 340 ,(2011) , 10.1038/NATURE10230
L. Poliseno, L. Salmena, L. Riccardi, A. Fornari, M. S. Song, R. M. Hobbs, P. Sportoletti, S. Varmeh, A. Egia, G. Fedele, L. Rameh, M. Loda, P. P. Pandolfi, Identification of the miR-106b~25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation Science Signaling. ,vol. 3, ,(2010) , 10.1126/SCISIGNAL.2000594
Benjamin P. Lewis, Christopher B. Burge, David P. Bartel, Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell. ,vol. 120, pp. 15- 20 ,(2005) , 10.1016/J.CELL.2004.12.035
Nataliya Razumilava, Steve F. Bronk, Rory L. Smoot, Christian D. Fingas, Nathan W. Werneburg, Lewis R. Roberts, Justin L. Mott, miR‐25 targets TNF‐related apoptosis inducing ligand (TRAIL) death receptor‐4 and promotes apoptosis resistance in cholangiocarcinoma Hepatology. ,vol. 55, pp. 465- 475 ,(2012) , 10.1002/HEP.24698
Naohiro Nishida, Makoto Nagahara, Tetsuya Sato, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii, Kenichi Sugihara, Yuichiro Doki, Masaki Mori, Microarray Analysis of Colorectal Cancer Stromal Tissue Reveals Upregulation of Two Oncogenic miRNA Clusters Clinical Cancer Research. ,vol. 18, pp. 3054- 3070 ,(2012) , 10.1158/1078-0432.CCR-11-1078
Giovanni Lanza, Manuela Ferracin, Roberta Gafà, Angelo Veronese, Riccardo Spizzo, Flavia Pichiorri, Chang-gong Liu, George A Calin, Carlo M Croce, Massimo Negrini, mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer Molecular Cancer. ,vol. 6, pp. 54- 54 ,(2007) , 10.1186/1476-4598-6-54
Thomas Simmen, Emily M. Lynes, Kevin Gesson, Gary Thomas, Oxidative Protein Folding in the Endoplasmic Reticulum: Tight Links to the Mitochondria-Associated Membrane (MAM) Biochimica et Biophysica Acta. ,vol. 1798, pp. 1465- 1473 ,(2010) , 10.1016/J.BBAMEM.2010.04.009
M. Maragkakis, M. Reczko, V. A. Simossis, P. Alexiou, G. L. Papadopoulos, T. Dalamagas, G. Giannopoulos, G. Goumas, E. Koukis, K. Kourtis, T. Vergoulis, N. Koziris, T. Sellis, P. Tsanakas, A. G. Hatzigeorgiou, DIANA-microT web server: elucidating microRNA functions through target prediction Nucleic Acids Research. ,vol. 37, pp. 273- 276 ,(2009) , 10.1093/NAR/GKP292