Towards a Molecular and Cellular Understanding of Remote Memory

摘要: While the molecular, cellular and systems mechanisms required for initial processing of memory have been intensively investigated by new field molecular cognition, those underlying permanent storage remain elusive. Here, we review neuroanatomical, pharmacological genetic results demonstrating that specific areas cortex play a critical role in remote memory. Imaging experiments rodents show are activated this activation is impaired manipulations block Accordingly, reversible inactivation cortical structures disrupts without affecting recent These open new, exciting window into studies suggest number interesting will address cellular, cognitive aspects poorly understood phase