Effects of nutritional intervention on body weight and body composition of obese psychiatric patients taking olanzapine

摘要: Objective: Weight gain is an established side effect of atypical antipsychotics in patients with severe mental illness (SMI). Previous studies have shown positive effects nutritional interventions weight loss. The purpose this study was to investigate the a intervention on body and composition SMI taking olanzapine Greece. Methods: Eighty-two treated (22 men, 60 women) and, 58 healthy controls (12 46 were followed for 3 mo. All obese, average mass index 33.12 +/- 0.74 kg/m(2) 94.61 2.50 kg. A program designed each participant based anthropometric characteristics, health profile, dietary needs. Pre- postintervention measurements performed. Results: Significant loss fat found from baseline mo (P < 0.05). However, had less significant decrease waist circumference 0.05) compared controls. male demonstrated greater decreases female participants Conclusion: Patients appear respond effectively demonstrating despite use olanzapine. Because gender differences may exist loss, it possible that should be taken into account more appropriate treatment obesity population. (C) 2009 Published by Elsevier Inc.