Lenalidomide alone or in combination with dexamethasone is highly effective in patients with relapsed multiple myeloma following allogeneic stem cell transplantation and increases the frequency of CD4+Foxp3+ T cells.

作者: M C Minnema , M S van der Veer , T Aarts , M Emmelot , T Mutis

DOI: 10.1038/LEU.2008.247

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摘要: Lenalidomide alone or in combination with dexamethasone is highly effective patients relapsed multiple myeloma following allogeneic stem cell transplantation and increases the frequency of CD4 + Foxp3 T cells

参考文章(7)
Meletios Dimopoulos, Andrew Spencer, Michael Attal, H. Miles Prince, Jean-Luc Harousseau, Anna Dmoszynska, Jesus San Miguel, Andrzej Hellmann, Thierry Facon, Robin Foà, Alessandro Corso, Zvenyslava Masliak, Marta Olesnyckyj, Zhinuan Yu, John Patin, Jerome B. Zeldis, Robert D. Knight, Lenalidomide plus Dexamethasone for Relapsed or Refractory Multiple Myeloma The New England Journal of Medicine. ,vol. 357, pp. 2123- 2132 ,(2007) , 10.1056/NEJMOA070594
Maria-Grazia Roncarolo, Silvia Gregori, Is FOXP3 a bona fide marker for human regulatory T cells European Journal of Immunology. ,vol. 38, pp. 925- 927 ,(2008) , 10.1002/EJI.200838168
Marc Beyer, Matthias Kochanek, Thomas Giese, Elmar Endl, Martin R. Weihrauch, Percy A. Knolle, Sabine Classen, Joachim L. Schultze, In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma Blood. ,vol. 107, pp. 3940- 3949 ,(2006) , 10.1182/BLOOD-2005-09-3671
J S Miguel, J Bladé, B Barlogie, K Anderson, M Gertz, M Dimopoulos, J Westin, P Sonneveld, H Ludwig, G Gahrton, M Beksac, J Crowley, A Belch, M Boccadaro, I Turesson, D Joshua, D Vesole, R Kyle, R Alexanian, G Tricot, M Attal, G Merlini, R Powles, P Richardson, K Shimizu, P Tosi, G Morgan, S V Rajkumar, B G M Durie, , J-L Harousseau, International uniform response criteria for multiple myeloma Leukemia. ,vol. 20, pp. 1467- 1473 ,(2006) , 10.1038/SJ.LEU.2404284
H. GLUCKSBERG, R. STORB, A. FEFER, C. D. BUCKNER, P. E. NEIMAN, R. A. CLIFT, K. G. LERNER, E. D. THOMAS, Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation. ,vol. 18, pp. 295- 304 ,(1974) , 10.1097/00007890-197410000-00001
Katayoun Rezvani, Stephan Mielke, Mojgan Ahmadzadeh, Yasemin Kilical, Bipin N. Savani, Josette Zeilah, Keyvan Keyvanfar, Aldemar Montero, Nancy Hensel, Roger Kurlander, A. John Barrett, High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood. ,vol. 108, pp. 1291- 1297 ,(2006) , 10.1182/BLOOD-2006-02-003996