gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation.
作者： Mariana C. Castells , Lloyd B. Klickstein , Kevin Hassani , Jose A. Cumplido , Mario E. Lacouture
DOI: 10.1038/87749
关键词:
摘要: We have identified the integrin alpha(v)beta3 as a ligand for mouse gp49B1, thus identifying new class of member family inhibitory immunoreceptors that bear C2-type immunoglobulin-like domains. The specific interaction was shown by both cell-protein and cell-cell binding assays. In addition, we found with gp49B1 on bone marrow-derived mast cells inhibited antigen-induced immunoglobulin E-mediated cell activation. Because neither nor exhibit substantive allelic variation, their newly appreciated may reflect an innate pathway down-regulating activity cells.
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