Application of REDOR NMR in natural product chemistry.
作者： Shigeru Matsuoka , Masayuki Inoue
DOI: 10.1039/B910230B
关键词:
摘要: Many natural products have molecular targets that are non-crystalline and insoluble biological matrices, such as proteins embedded in lipid membrane, cell membranes, walls. To understand the action mechanisms, it is essential to determine binding structure with atomic-level resolution. For structural studies of solids, high resolution distance measurements using solid-state nuclear magnetic resonance (NMR) indispensable techniques, which rotational-echo double-resonance (REDOR) one most widely used methods. This feature article introduces basic concepts REDOR NMR its application study matrices.
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