Recent Advances in the Study of the Bioactive Conformation of Taxol
作者： Liang Sun , Carlos Simmerling , Iwao Ojima
关键词:
摘要: Paclitaxel is one of the most important chemotherapeutic drugs in fight against cancer. This minireview covers recent advances study bioactive conformation paclitaxel tubulin/microtubules. The tubulin-bound structure has been studied by means photoaffinity labeling, cryo-electron microscopy, solid-state NMR, molecular modeling, MD simulations and synthesis conformationally restrained analogues mimics. since it could provide critical information that would allow design novel with simpler structures and/or increased potency
sci-hub.se 参考文章(75)
Younkee Paik, Chao Yang, Belhu Metaferia, Shoubin Tang, Susan Bane, Rudravajhala Ravindra, Natasha Shanker, Ana A. Alcaraz, Scott A. Johnson, Jacob Schaefer, Robert D. O'Connor, Lynette Cegelski, James P. Snyder, David G. I. Kingston, Rotational-Echo Double-Resonance NMR Distance Measurements for the Tubulin-Bound Paclitaxel Conformation Journal of the American Chemical Society. ,vol. 129, pp. 361- 370 ,(2007) , 10.1021/JA0656604
Iwao Ojima, Scott D. Kuduk, Subrata Chakravarty, Recent advances in the medicinal chemistry of taxoid anticancer agents Advances in Medicinal Chemistry. ,vol. 4, pp. 69- 124 ,(1999) , 10.1016/S1067-5698(99)80004-2
S. Rao, N.E. Krauss, J.M. Heerding, C.S. Swindell, I. Ringel, G.A. Orr, S.B. Horwitz, 3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin. Journal of Biological Chemistry. ,vol. 269, pp. 3132- 3134 ,(1994) , 10.1016/S0021-9258(17)41836-9
Matteo Magnani, Francesco Ortuso, Simonetta Soro, Stefano Alcaro, Anna Tramontano, Maurizio Botta, The betaI/betaIII-tubulin isoforms and their complexes with antimitotic agents. Docking and molecular dynamics studies. FEBS Journal. ,vol. 273, pp. 3301- 3310 ,(2006) , 10.1111/J.1742-4658.2006.05340.X
A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu, C. Smigal, M. J. Thun, Cancer statistics, 2006. CA: A Cancer Journal for Clinicians. ,vol. 56, pp. 106- 130 ,(2006) , 10.3322/CANJCLIN.56.2.106
Srinivasa Rao, George A. Orr, Ashok G. Chaudhary, David G. I. Kingston, Susan Band Horwitz, Characterization of the Taxol Binding Site on the Microtubule 2-(m-AZIDOBENZOYL)TAXOL PHOTOLABELS A PEPTIDE (AMINO ACIDS 217-231) of β-TUBULIN Journal of Biological Chemistry. ,vol. 270, pp. 20235- 20238 ,(1995) , 10.1074/JBC.270.35.20235
Mary Ann Jordan, Leslie Wilson, Microtubules as a target for anticancer drugs. Nature Reviews Cancer. ,vol. 4, pp. 253- 265 ,(2004) , 10.1038/NRC1317
Iwao Ojima, Xudong Geng, Songnian Lin, Paula Pera, Ralph J Bernacki, Design, synthesis and biological activity of novel C2-C3′ N-Linked macrocyclic taxoids Bioorganic & Medicinal Chemistry Letters. ,vol. 12, pp. 349- 352 ,(2002) , 10.1016/S0960-894X(01)00747-8
Scott J. Weiner, Peter A. Kollman, David A. Case, U. Chandra Singh, Caterina Ghio, Guliano Alagona, Salvatore Profeta, Paul Weiner, A NEW FORCE FIELD FOR MOLECULAR MECHANICAL SIMULATION OF NUCLEIC ACIDS AND PROTEINS Journal of the American Chemical Society. ,vol. 106, pp. 765- 784 ,(1984) , 10.1021/JA00315A051
Shoubin Tang, Chao Yang, Peggy Brodie, Susan Bane, Rudravajhala Ravindra, Shubhada Sharma, Yi Jiang, James P. Snyder, David G. I. Kingston, Bridging Converts a Noncytotoxicnor-Paclitaxel Derivative to a Cytotoxic Analogue by Constraining It to the T-Taxol Conformation Organic Letters. ,vol. 8, pp. 3983- 3986 ,(2006) , 10.1021/OL061438S