Antioxidant therapy in human endocrine disorders.

摘要: Reactive oxygen species (ROS) have deleterious or beneficial effects; this dual nature of ROS means that act as intracellular signaling molecules and defense mechanisms against micro-organisms. An overproduction results in oxidative stress, a process damages cell structures, including lipids, proteins, DNA. Oxidative stress plays major role various human disease states, endocrine dysfunction. As safeguard several endogenous nonenzymatic enzymatic antioxidant systems exist. Antioxidants can delay prevent are widely used the hope maintaining health preventing diseases. Although early studies suggested supplements promoted health, later clinical trials revealed it may not be true all cases. In article, we provide brief review pathophysiologic aspects number most commonly endocrionopathies (diabetes, male female infertility thyroid diseases) therapeutic potentials existing strategies. We focus on discuss implications their results. Based data reported so far, conclude challenge us to design better future, with particular emphasis identifying 1) appropriate doses 2) selecting right populations 3) treating for optimal durations 4) specific targeting mechanisms.