Acute administration of methylenedioxymethamphetamine: comparison with the neurochemical effects of its N-desmethyl and N-ethyl analogs.

摘要: The acute and long-term neurochemical effects of three methylenedioxyamphetamine analogs were examined in the serotonergic system rat brain. Methylenedioxymethamphetamine as well its N-desmethyl N-ethyl derivatives depleted cortical serotonin (5HT) concentrations to less than 30% control 3 h after drug administration. All compounds also very similar their on [3H]5HT release from superfused striatal slices. Increasing size N-alkyl substituent did appear reduce potency agent for inducing [3H]dopamine release. One week following administration 5HT had returned levels animals treated with derivative while other two produced persistent depletions transmitter concentrations. latter drugs correlated a significant decrease whole brain synaptosomal uptake indicating nerve terminal damage. N-ethyl-methylenedioxyamphetamine no effect at one week. (+) stereoisomer was slightly more potent (-) enantiomer producing depletion previously shown N-methyl suggesting mechanisms may be responsible neurotoxic effects.