Neurochemical Effects of Methylenedioxymethamphetamine in the Rat: Acute Versus Long-Term Changes

摘要: Amphetamine-like central stimulants are one of the most well-studied classes pharmacological agents known today. This is due to fact that their behavioral activity believed be mediated primarily by monoamines, which themselves have been scrutinized sufficiently earned title “classical transmitters.” In spite attention given this class and relatively well-described neurochemical activities, there remains a great deal about these drugs we do not understand. The neurotoxicity associated with high doses many unexplained actions. Although term dose used, it important point out often in range humans exposed. particularly true case 3,4-methylenedioxymethamphetamine (MDMA), as has described elsewhere book. amphetamines selective, affects neuronal systems through mediate effects, i.e., monoaminergic systems. Thus amphetamine, cause majority its stimulant activities dopamine release, causes persistent damage selectively dopaminergic processes [1]. Methamphetamine, also potent releaser 5-HT, neurotoxic both serotonergic [2]. Finally, selective p-chloroamphetamine (PCA) correlates 5-HT release presumed basis most, though all, behavior effects [3].