Role of the dopaminergic nigrostriatal pathway in methamphetamine-induced depression of the neostriatal serotonergic system
作者： Michel Johnson , Donna M. Stone , Glen R. Hanson , James W. Gibb
DOI: 10.1016/0014-2999(87)90616-9
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摘要: The prevention of the decrease in neostriatal trytophan hydroxylase (TPH) activity with a single dose methamphetamine (MA) was attempted by lesioning nigrostriatal dopaminergic projections bilateral nigral injections 6-hydroxydopamine (6-OHDA). rats were injected MA (10 mg/kg) 11 days later, and killed 3 h after injection. 6-OHDA lesions prevented TPH neostriatum, while enzyme slightly attenuated hippocampus unaffected frontal cortex. This study demonstrates: (1) that attenuation can be selected brain area destroying its afferents, (2) implicates central dopamine (DA), or metabolite, observed injection MA.
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