Effects of repeated administration of a high dose of methamphetamine on dopamine and glutamate release in rat striatum and nucleus accumbens
作者： Tomohiro Abekawa , Tetsuro Ohmori , Tsukasa Koyama
DOI: 10.1016/0006-8993(94)90033-7
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摘要: Abstract We examined effects of a high dose methamphetamine (MA) (4.02 mg free base/kg, s.c., at 2-h intervals, 4 injections) on extracellular concentrations monoamines such as dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic (HVA), and 5-hydroxyindoleacetic (5-HIAA) those glutamate other several amino acids in rat striatum (ST) nucleus accumbens (NA) using vivo microdialysis. Five days after the microdialysis, tissue were measured. The toxic MA markedly increased DA, decreased DOPAC, HVA 5-HIAA both ST NA. Magnitude increase DA release was not different between Extracellular showed gradual ST, but NA, while no changes Tissue serotonin (5-HT) to 43–58% control values whereas DOPAC 43–54% decrease These data suggest that marked is directly related MA-induced dopaminergic neurotoxicity. found only may be damage ST. It enhanced act synergistically cause neurotoxicity However, enhancement did appear essential for serotonergic
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