Metabotropic Glutamate Receptors and Neurodegeneration
作者： Valeria Bruno , Giuseppe Battaglia , Agata Copani , Giacomo Casabona , Marianna Storto
DOI: 10.1007/978-1-4419-8959-8_6
关键词:
摘要: Metabotropic glutamate (mGlu) receptors, which exert a modulatory effect on excitatory synaptic transmission, are considered as potential targets for neuroprotective drugs and the advent of potent centrally available subtype-selective ligands has lead to an extensive investigation role individual mGlu receptor subtypes in neurodegeneration. Pharmacological blockade mGlu1 or -5 receptors pharmacological activation mGlu2/3 mGlu4/7/8 produces neuroprotection variety vitro vivo models. MGlu1 antagonists promising treatment brain ischemia prophylaxis neuronal damage induced by hyperactivity. MGlu5 may limit hyperactivity NMDA because mGlu5 physically functionally connected membranes, suggesting application chronic neurodegenerative disorders, such Amyotrophic Lateral Sclerosis (ALS) Alzheimer’s disease (AD). MGlu2/3 agonists inhibit release, also promote synthesis release neurotrophic factors astrocytes. These therefore have broad agents eNS disorders. Finally, potently seizure
springer.com
core.ac.uk
elsevier.com
sci-hub.st 参考文章(121)
James A. Monn, Matthew J. Valli, Steven M. Massey, Rebecca A. Wright, Craig R. Salhoff, Bryan G. Johnson, Trevor Howe, Charles A. Alt, Gary A. Rhodes, Roger L. Robey, Kelly R. Griffey, Joseph P. Tizzano, Mary J. Kallman, David R. Helton, Darryle D. Schoepp, Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. Journal of Medicinal Chemistry. ,vol. 40, pp. 528- 537 ,(1997) , 10.1021/JM9606756
V. Bruno, G. Battaglia, G. Casabona, A. Copani, F. Caciagli, F. Nicoletti, Neuroprotection by Glial Metabotropic Glutamate Receptors Is Mediated by Transforming Growth Factor-β The Journal of Neuroscience. ,vol. 18, pp. 9594- 9600 ,(1998) , 10.1523/JNEUROSCI.18-23-09594.1998
S. Alagarsamy, M. J. Marino, S. T. Rouse, R.W. Gereau, S. F. Heinemann, P. J. Conn, Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems Nature Neuroscience. ,vol. 2, pp. 234- 240 ,(1999) , 10.1038/6338
RW Gereau, PJ Conn, Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1 The Journal of Neuroscience. ,vol. 15, pp. 6879- 6889 ,(1995) , 10.1523/JNEUROSCI.15-10-06879.1995
Ryuichi Shigemoto, Ayae Kinoshita, Eiki Wada, Sakashi Nomura, Hitoshi Ohishi, Masahiko Takada, Peter J. Flor, Akio Neki, Takaaki Abe, Shigetada Nakanishi, Noboru Mizuno, Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. The Journal of Neuroscience. ,vol. 17, pp. 7503- 7522 ,(1997) , 10.1523/JNEUROSCI.17-19-07503.1997
M Niethammer, E Kim, M Sheng, Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases The Journal of Neuroscience. ,vol. 16, pp. 2157- 2163 ,(1996) , 10.1523/JNEUROSCI.16-07-02157.1996
A Copani, S Stanzani, G Leanza, F Nicoletti, A Russo, V Bruno, R Pellitteri, G Battaglia, ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS PROTECTS CULTURED NEURONS AGAINST APOPTOSIS INDUCED BY BETA -AMYLOID PEPTIDE Molecular Pharmacology. ,vol. 47, pp. 890- 897 ,(1995)
Tomohiro Abekawa, Tetsuro Ohmori, Tsukasa Koyama, Effects of repeated administration of a high dose of methamphetamine on dopamine and glutamate release in rat striatum and nucleus accumbens Brain Research. ,vol. 643, pp. 276- 281 ,(1994) , 10.1016/0006-8993(94)90033-7
Jian Cheng Tu, Bo Xiao, Scott Naisbitt, Joseph P. Yuan, Ronald S. Petralia, Paul Brakeman, Andrew Doan, Vinay K. Aakalu, Anthony A. Lanahan, Morgan Sheng, Paul F. Worley, Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins Neuron. ,vol. 23, pp. 583- 592 ,(1999) , 10.1016/S0896-6273(00)80810-7
Domenico E. Pellegrini-Giampietro, Andrea Cozzi, Fiamma Peruginelli, Patrizia Leonardi, Elena Meli, Roberto Pellicciari, Flavio Moroni, 1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia. European Journal of Neuroscience. ,vol. 11, pp. 3637- 3647 ,(1999) , 10.1046/J.1460-9568.1999.00786.X