1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors
作者： Andres Avelino Trabanco-Suarez , Guillaume Albert Jacques Duvey , Vanthea Nhem , Robert Johannes Lutjens , Gregor James MacDonald
DOI:
关键词: Glutamate receptor 、 Receptor 、 Pharmacology 、 Chemistry 、 Metabotropic receptor 、 Metabotropic glutamate receptor 2 、 Epilepsy 、 Schizophrenia 、 Allosteric regulation
摘要: The present invention relates to novel compounds, in particular pyridinone de- rivat ives according Formula (I) wherein all radicals are defined the application and claims. compounds accord- ing positive allosteric modulators of metabotropic receptors - sub- type 2 (''mGluR2'') which useful for treatment or prevention neurological psychiatric disorders associated with glutamate dysfunction diseases mGluR2 subtype is involved. In particular, such central nervous system selectedfrom group anxiety, schizophrenia, migraine, depression, epilepsy. also directed pharmaceutical composit ions processes prepare compositions, as well use
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