3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
作者： Andres Avelino Trabanco-Suarez , Guillaume Albert Jacques Duvey , Gregor James Macdonald , Jose Maria Cid-Nunez
DOI:
关键词: Chemistry 、 Metabotropic glutamate receptor 、 Stereochemistry 、 Metabotropic glutamate receptor 2 、 Allosteric regulation 、 Tetrahydropyran 、 Glutamate receptor 、 Metabotropic receptor
摘要: The present invention relates to novel compounds, in particular pyr idinone derivatives according Formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof so lvate wherein all radicals are defined the application and claim s. compounds positive allosteric modulato rs of metabotropic glutamate receptors subtype 2 ( mGluR2 ) which useful for treatment prevention neurological psychiatric disorders ssociated with dysfunction diseases subtyp e is involved. In particular, such ce ntralnervous system selected from group anxiety,schizophren ia, migraine, depression, epilepsy. also directed ph armaceutical compositions processes prepare c ompositions, as well use
google.co.bw参考文章(1,439)
Philip Seeman, Glutamate and dopamine components in schizophrenia Journal of Psychiatry & Neuroscience. ,vol. 34, pp. 143- 149 ,(2009)
Jan Passchier, Antony Gee, Antoon Willemsen, Willem Vaalburg, Aren van Waarde, Measuring drug-related receptor occupancy with positron emission tomography. Methods. ,vol. 27, pp. 278- 286 ,(2002) , 10.1016/S1046-2023(02)00084-1
Sebastian Herminghaus, Lutz Frölich, Corrina Gorriz, Ullrich Pilatus, Thomas Dierks, Hans-Jörg Wittsack, Heinrich Lanfermann, Konrad Maurer, Friedhelm E. Zanella, Brain metabolism in Alzheimer disease and vascular dementia assessed by in vivo proton magnetic resonance spectroscopy Psychiatry Research: Neuroimaging. ,vol. 123, pp. 183- 190 ,(2003) , 10.1016/S0925-4927(03)00071-4
Anne-Sophie Addex Pharmaceuticals S.A. Bessis, Yves Addex Pharmaceuticals S.A. Thollon, Sonia-Maria Addex Pharmaceuticals S.A. Poli, Béatrice Addex Pharmaceuticals S.A. Bonnet, Mark Addex Pharmaceuticals S.A. Epping-Jordan, Jean-Philippe Addex Pharmaceuticals S.A. Rocher, Nicholas Addex Pharmaceuticals S.A. Poirier, Christelle Addex Pharmaceuticals S.A. Bolea, Alkynyl derivatives as modulators of metabotropic glutamate receptors ,(2005)
Hussien A. Al-Shamma, Christen Anderson, Emil Chuang, Remy Luthringer, Andrew J. Grottick, Erin Hauser, Michael Morgan, William Shanahan, Bradley R. Teegarden, William J. Thomsen, Dominic Behan, Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine2A Inverse Agonist for the Treatment of Insomnia Journal of Pharmacology and Experimental Therapeutics. ,vol. 332, pp. 281- 290 ,(2010) , 10.1124/JPET.109.160994
Andrew A. Nierenberg, George I. Papakostas, Timothy Petersen, Heidi D. Montoya, John J. Worthington, Joyce Tedlow, Jonathan E. Alpert, Maurizio Fava, Lithium augmentation of nortriptyline for subjects resistant to multiple antidepressants. Journal of Clinical Psychopharmacology. ,vol. 23, pp. 92- 95 ,(2003) , 10.1097/00004714-200302000-00013
Brigitte Pettmann, Christopher E Henderson, Neuronal Cell Death Neuron. ,vol. 20, pp. 633- 647 ,(1998) , 10.1016/S0896-6273(00)81004-1
M. Olive, Metabotropic Glutamate Receptor Ligands as Potential Therapeutics for Addiction Current Drug Abuse Reviews. ,vol. 2, pp. 83- 98 ,(2009) , 10.2174/1874473710902010083
Gordon William Rewcastle, Alexander James Bridges, Robert Frederick Meyer, William Alexander Denny, David Fry, Andrew Mark Thompson, Alan Kraker, Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family ,(1995)
JL Arriza, WA Fairman, JI Wadiche, GH Murdoch, MP Kavanaugh, SG Amara, Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex The Journal of Neuroscience. ,vol. 14, pp. 5559- 5569 ,(1994) , 10.1523/JNEUROSCI.14-09-05559.1994