Human exposure to airborne aniline and formation of methemoglobin: a contribution to occupational exposure limits

摘要: Aniline is an important starting material in the manufacture of polyurethane-based plastic materials. Aniline-derived methemoglobinemia (Met-Hb) well described exposed workers although information on dose-response association limited. We used experimental design to study between aniline air with formation Met-Hb blood and elimination urine. A 6-h exposure 2 ppm 19 non-smoking volunteers resulted a time-dependent increase The maximum level (mean 1.21 ± 0.29 %, range 0.80-2.07 %) excretion urine 168.0 51.8 µg/L, 79.5-418.3 µg/L) were observed at end exposure, both parameters rapidly decreasing after exposure. After 24 h, mean (0.65 0.18 returned basal prior (0.72 0.19 %); whereas, slightly elevated levels still present (means 17.0 17.1 vs. 5.7 3.8 µg/L). No differences males females as slow fast acetylators found. results obtained also comparable those four 8-h Maximum 1.57 % 305.6 respectively. Overall, our contribute risk assessment result, protection from aniline-derived adverse health effects workplace.