Sex differences in the production of methaemoglobinaemia by 4-aminopropiophenone
作者： J. E. Bright , A. C. Woodman , T. C. Marrs , S. G. Wood
DOI: 10.3109/00498258709047177
关键词:
摘要: A methaemoglobin former, 4-aminopropiophenone (p-aminopropiophenone, PAPP), which is active only after metabolic activation in vivo, exhibits a sex difference male Beagle dogs and bitches. Bitches produced more for given dose of PAPP than dogs. The probable reason this was lower rate N-hydroxylation
sci-hub.se 参考文章(2)
Edward J. Calabrese, Principles of animal extrapolation ,(1983)
J.W. Scawin, D.W. Swanston, T.C. Marrs, The acute oral and intravenous toxicity of p-aminopropiophenone (PAPP) to laboratory rodents. Toxicology Letters. ,vol. 23, pp. 359- 365 ,(1984) , 10.1016/0378-4274(84)90034-1