Development and Treatment of Tertiary Hyperparathyroidism in Patients with Pseudohypoparathyroidism Type 1B
作者： Nicola M. Neary , Diala El-Maouche , Rachel Hopkins , Steven K. Libutti , Arnold M. Moses
DOI: 10.1210/JC.2012-1655
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摘要: Context: Pseudohypoparathyroidism type 1B (PHP1B) patients have PTH resistance at the renal proximal tubule and develop hypocalcemia secondary hyperparathyroidism. Hyperparathyroid bone disease also develops in some patients. PHP1B are theoretical risk of developing tertiary Setting: Patients were studied a clinical research center. Patients: Five female presented with hypercalcemia elevated PTH. Intervention: either underwent parathyroidectomy (n = 4) or received cinacalcet 1). Main Outcome Measures: Serum calcium serially measured before after intervention. Results: developed concomitantly serum levels (range, 235–864 ng/liter) requiring termination vitamin D therapy (time diagnosis, 21–42 yr; median, 34 yr), consistent Four removal one 2) two enlarged par...
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