Cinacalcet as adjunctive therapy in pseudohypoparathyroidism type 1b

作者: Tarak Srivastava , Jeffrey Krudys , Neil J. Mardis , Judith Sebestyen-VanSickle , Uri S. Alon

DOI: 10.1007/S00467-015-3271-7

关键词: Imprinting (psychology)HormoneInternal medicineNephrologyPseudohypoparathyroidism Type 1bCinacalcetEndocrinologyMedicineIn patientCalcium-sensing receptorParathyroid hormone

摘要: Background In patients with pseudohypoparathyroidism type 1b (PHP1b) due to a tissue-specific imprinting defect in the G-protein α-subunit, skeletal disorders can arise from bones being sensitive parathyroid hormone (PTH) while kidneys remain resistant this hormone.

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