An association of prodynorphin polymorphisms and opioid dependence in females in a Chinese population.

摘要: Prodynorphin (PDYN) binds to kappa-opioid receptors and is known regulate dopaminergic tone, making this system important for the reinforcing rewarding properties of drugs abuse such as opioids. The binding dynorphins also produces aversive states that may affect development opioid dependence. Recent animal results have shown PDYNknockout mice show decreased ethanol consumption; however, finding was restricted female mice. We were interested analyse a possible gender specificity dynorphin effects in humans end three single-nucleotide polymorphisms (SNPs) PDYN genotyped Chinese population 484 dependents 374 controls. An interaction between sex genotype found dependents. Chi-squared tests association revealed distributions SNPs rs1997794 (P = 0.019) rs1022563 0.006) promoter 3' region PDYN, respectively, be associated with Therefore, are significantly risk developing dependence; effect only seen females. These data suggest should studied additional opioid-dependent populations an emphasis on regions gene.