The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.

摘要: The renal effects of angiotensin II(AII) are attributed to AT1 receptors. In contrast, the function AT2 receptors in unknown. Using a microdialysis technique, we monitored changes interstitial fluid (RIF) prostaglandin E2 (PGE2) and cyclic guanosine 3', 5'-monophosphate (cGMP) response dietary sodium (Na) depletion alone, or Na normal diet combined with receptor blocker, Losartan, PD 123319 (PD), II, individually conscious rats. significantly increased PGE2 cGMP. During depletion, Losartan decreased did not change Combined administration diet, RIF cGMP II. Neither nor PD, combined, changed II produced significant decrease respectively. These data demonstrate that activation reninangiotensin system during increases mediates production PGE2. blockade potentiates angiotensin-induced at receptor.