Translocation and rearrangement of myeloperoxidase gene in acute promyelocytic leukemia.
作者： S. Weil , G. Rosner , M. Reid , R. Chisholm , R. Lemons
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摘要: Acute promyelocytic leukemia (subtype M3) is characterized by malignant promyelocytes exhibiting an abundance of abnormally large or aberrant primary granules. Myeloperoxidase (MPO) activity these azurophilic granules, as assessed cytochemical staining, unusually intense. In addition, M3 universally associated with a chromosomal translocation, t(15;17)(q22;q11.2). this report, the MPO gene was localized to human chromosome 17 (q12-q21), region breakpoint on in t(15;17), somatic cell hybrid analysis and situ hybridization. By means complementary DNA clones for hybridization Southern blot analysis, effect specific translocation examined. all cases examined, translocated 15. Genomic analyses indicate rearrangement cells two four These findings suggest that may be pivotal pathogenesis acute leukemia.
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