Increased placental apoptosis in intrauterine growth restriction

摘要: Abstract OBJECTIVES: Our purpose was to investigate a possible role for apoptosis in the pathophysiologic mechanisms of intrauterine growth restriction. STUDY DESIGN: Placental samples were obtained from 43 uncomplicated third-trimester pregnancies and 26 complicated by The definition used identify cases restriction depended on three criteria: clinical evidence suboptimal growth, ultrasonographic deviation an appropriate percentile, individualized birth weight ratios RESULTS: Quantification (medians interquartile ranges) resulted following values: normal third trimester ( n  = 43) 0.14% cells (0.08% 0.20%) = 26) 0.24% (0.16% 0.29%). incidence significantly higher placentas with compared p U test). CONCLUSIONS: These results suggest that may play restriction.(Am J Obstet Gynecol 1997;177:401)