Non-coding genetic variation shaping mental health

摘要: Over 98% of our genome is non-coding and now recognised to have a major role in orchestrating the tissue specific stimulus inducible gene expression pattern which underpins wellbeing mental health. The responds functionally environment at all levels, encompassing span from psychological physiological challenge. pattern, termed transcriptome, ultimately gives us neurochemistry. Therefore modulator how genes are regulated response life experiences. Superimposed on aforementioned DNA framework vast body genetic variation elements that control challenges. These differences, polymorphisms, allow for differential element same challenge thus potentially allowing ‘individuality’ modulation transcriptome. This review will focus fundamental mechanism defining psychiatric wellbeing, namely can be correlated with challenges, resulting altered neurochemistry consequently may shape behaviour.