Retrospective evaluation of the outcomes of children with diffuse intrinsic pontine glioma treated with radiochemotherapy and valproic acid in a single center

摘要: Diffuse intrinsic pontine glioma is a pediatric oncologic disease with dismal prognosis and no effective treatment. Since 2007, our patients have been using valproic acid as prophylactic anticonvulsant. We undertaken retrospective study in order to evaluate the influence of valproate outcomes children this center. Patients were treated weekly carboplatin vincristine received conformal radiotherapy, either concurrent or sequential. Event-free survival overall not 6.5 7.8 months. Accelerated failure time model (a parametric multivariate regression test for time-to-failure data) showed statistically significant superiority median event-free (6.5 vs. 9.5 months patients; HR 0.54–95 % CI 0.33–0.87; p < 0.05) also (7.8 13.4 0.60–95 0.37–0.98; = 0.05).