Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma.
作者： Caroline Happold , Thierry Gorlia , Olivier Chinot , Mark R. Gilbert , L. Burt Nabors
关键词: Internal medicine 、 Medicine 、 Levetiracetam 、 Survival analysis 、 Clinical trial 、 Oncology 、 Pharmacotherapy 、 Dacarbazine 、 Cilengitide 、 Surgery 、 Chemoradiotherapy 、 Temozolomide
摘要: PurposeSymptomatic epilepsy is a common complication of glioblastoma and requires pharmacotherapy. Several uncontrolled retrospective case series post hoc analysis the registration trial for temozolomide indicated an association between valproic acid (VPA) use improved survival outcomes in patients with newly diagnosed glioblastoma.Patients MethodsTo confirm hypothesis suggested above, combined antiepileptic drug at start chemoradiotherapy was performed pooled patient cohort (n = 1,869) four contemporary randomized clinical trials glioblastoma: AVAGlio (Avastin Glioblastoma; NCT00943826), CENTRIC (Cilengitide, Temozolomide, Radiation Therapy Treating Patients With Newly Diagnosed Glioblastoma Methylated Gene Promoter Status; NCT00689221), CORE Unmethylated Promoter...
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